Zestril is used for treating high blood pressure alone or with other medicines. It is used along with other medicines to manage heart failure or improve survival after a heart attack. Zestril is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This helps to lower blood pressure.
Use Zestril as directed by your doctor.
- Take Zestril by mouth with or without food.
- If you miss a dose of Zestril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Zestril.
Store Zestril at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zestril out of the reach of children and away from pets.
Active Ingredient: Lisinopril.
Do NOT use Zestril if:
- you are allergic to any ingredient in Zestril
- you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor
- you are in your second or third trimester of pregnancy
- the patient is a child with severe kidney problems.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Zestril. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you are able to become pregnant
- if you have a history of heart problems (eg, heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, kidney problems, or diabetes
- if you have a history of stroke, recent heart attack, or kidney transplant
- if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma)
- if you are dehydrated or have low blood volume
- if you have high blood potassium levels, low blood sodium levels, or are on a low salt (sodium) diet
- if you are on dialysis or are scheduled to have major surgery.
Some medicines may interact with Zestril. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased
- Aldosterone blockers (eg, eplerenone), potassium-sparing diuretics (eg, spironolactone, triamterene), or potassium supplements because the risk of high blood potassium levels may be increased
- Insulin, sulfonylureas (eg, glipizide), or other oral diabetes medicines (eg, metformin) because the risk of low blood sugar may be increased
- Gold-containing medicines (eg, auranofin) because flushing, nausea, vomiting, and low blood pressure may occur
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) because they may decrease Zestril’s effectiveness
- Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by Zestril.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Zestril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.